Answer:
critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To identify the role of individual receptor subunits in ethanol-induced behaviors, we developed a novel class of ultra-sensitive ethanol receptors (USERs) that allow activation of a single receptor subunit population sensitized to extremely low ethanol concentrations. USERs were created by mutating as few as four residues in the extracellular loop 2 region of glycine receptors (GlyRs) or γ-aminobutyric acid type A receptors (GABAARs), which are implicated in causing many behavioral effects linked to ethanol abuse. USERs, expressed in Xenopus oocytes and tested using two-electrode voltage clamp, demonstrated an increase in ethanol sensitivity of 100-fold over wild-type receptors by significantly decreasing the threshold and increasing the magnitude of ethanol response, without altering general receptor properties including sensitivity to the neurosteroid, allopregnanolone. These profound changes in ethanol sensitivity were observed across multiple subunits of GlyRs and GABAARs. Collectively, our studies set the stage for using USER technology in genetically engineered animals as a unique tool to increase understanding of the neurobiological basis of the behavioral effects of ethanol.
Explanation:
make me as brain liest
Select the correct answer.
Franklin has narrowed his choices for city council down to two candidates. He has specific questions for each candidate. The closest Franklin can get to guaranteeing that he will get answers to these questions is
A.
by watching a TV debate between the two candidates.
B.
by asking his friends and neighbors about the two candidates.
C.
by asking questions at a town hall for each candidate.
D.
by watching each candidate's television advertisements.
Who was the last confederate soldier to surrender
A. Fredrick Douglass
B. Sen. James Henry Lane
C. Gen. Stand Watie
D. Col. William Quantrill
Answer: Gen. Stand Watie
Explanation: The last significant Confederate active force to surrender was the Confederate allied Cherokee Brigadier General Stand Watie and his Indian soldiers on June 23. The last Confederate surrender occurred on November 6, 1865, when the Confederate warship CSS Shenandoah surrendered at Liverpool, England.
Answer:
c
Explanation:
on edge2021
NOW HURRY!! HELP summarize cinderella
Answer:
a girl who loses her shoe and is abused by her step mother and step sisters she goes to a ball and meets a prince but leaves behind her glass slipper the prince goes out and searches for her he finds her and they live happily ever after
Which of these was a precedent set by the first President of the United States, George Washington?
Answer:
the answer is B) the tradition of only serving two terms
Explanation:
Answer:
C
Explanation:
How do citizens participate in community service
What was the significance of the Iroquois Confederacy?
Might Be This One:
The Iroquois Confederacy were six tribes who lived, fought, ate, built, and worked together to better their lives. They created laws and government. Some of their ideas worked so well they helped our country create its first democratic government and constitution.
Most likely this one:
The Peacemaker established clans within the nations of the Iroquois Confederacy. The clan system united the nations and ensured peace among them. They are still an important part of the identity of Iroquois people today. They were an influence on the Founders of America.
What is a main reason the Creeks fought for sovereign rights?
A.They believed in the right to worship freely.
B.They sought the ability to trade in open markets.
C.They wanted equal claim to lands where they lived.
D.They wanted to assimilate into the United States.
Answer:
C. They wanted equal claim to lands where they lived.
Explanation:
I did the test on E.D.G.E.N.U.I.T.Y
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How did the political systems of the Shang and Zhou dynasties compare?
Both the Shang and Zhou dynasties used elections to determine their leaders.
Both the Shang and Zhou dynasties had strong central governments led by cruel kings.
Shang leaders were elected by the people, while Zhou leaders were appointed.
The Shang dynasty had a central government, while the Zhou dynasty relied on feudalism.
Answer:
on edg it :is Both the Shang and Zhou dynasties used elections to determine their leaders.
Both the Shang and Zhou dynasties had strong central governments led by cruel kings.
Shang leaders were elected by the people, while Zhou leaders were appointed.
The Shang dynasty had a central government, while the Zhou dynasty relied on feudalism.
Explanation:
Answer:
the answer is D.
Explanation:
WILL GIVE BRAINLIEST!!!!!!!!
Before European arrival, Native American paths both connected and pitted Native American nations against each other.
True
False
Explain the causes of the conflict between North Vietnam and the United States.
Answer:
The conflict was because the U.S didnt want communist to spread over to vietnam so vietnam broke up to nort vietnam and south vietnam the us sidded with south vietnam because they didnt want communist.
Explanation:
Hope this helps
Who was the Cheif Justice at the time of McCulloch v Maryland?
Answer:
John Marshall
Explanation:
McCulloch v. Maryland, U.S. Supreme Court case decided in 1819, in which Chief Justice John Marshall affirmed the constitutional doctrine of Congress’ “implied powers.” It determined that Congress had not only the powers expressly conferred upon it by the Constitution but also all authority “appropriate” to carry out such powers.
Capitalism is built on the principle of blank ownership.
Answer:
Capitalism is built on the principle of private ownership.
Answer:
The two principles that form the basis of capitalism are private ownership and free markets, as this economic system occurs through less state intervention.
What is capitalism?
It corresponds to a system where the objective is to generate profit through private ownership and means of production, which can be industries, land and machinery, which are capable of generating income through work.
Therefore, globalization was a factor that strengthened capitalism, as countries trade with each other in order to achieve competitive advantages and profitability.
Find out more about capitalism here:
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What were some of the founding ideals that the United States was created upon
Answer:
Founded on a Set of Beliefs. Among them was the idea that all people are created equal, whether European, Native American, or African American, and that these people have fundamental rights, such as liberty, free speech, freedom of religion, due process of law, and freedom of assembly.
Explanation:
...............
......Someone help
Answer:
C. Diseases spread through American Indian communities
Answer:
its c
Explanation:
Once they arrive the europeans were very unhygienic during the time they arrived to America there were many diseases in Europe in which case they europeans had transmitted diseases to the Indians.
A very small percentage of African Americans in the 13 Colonies were A. classified as free citizens B. slaves C. Indians
Answer:
A classified as free citizens. im pretty sure
Justinian's Code is
Question 1 options:
A secret code to unite the Western and Eastern Empires
A collection of laws that arranged the empire’s existing laws and legal opinions into a clear system
A law that gave women the right to vote
None of the above
The Justinian's Code is the collection of laws that arranged the empire’s existing laws and legal opinions into a clear system.
What are the Code of Justinian?During the Byzantine empire, the Code of Justinian means the legal code that consisted of the various sets of laws and legal interpretations that were collected and codified by scholars under the direction of Byzantine Emperor Justinian.
The purpose of these Code of Justinian, as sets of laws was to create an acceptable and universal set of laws that all of the Byzantine Empire could follow and this gave a precedence over any local laws and prevented any contradictions in court rulings.
Read more Code of Justinian
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How did Darius I create unity?
Answer:
How long did Darius I rule? 522-486 BC. What type of government did Darius I set up? Explain. ... What did Darius do to encourage unity? he had 100 miles
Explanation:
Which battle resulted in many American soldiers deserting the army? (5 points)
Group of answer choices
Trenton
Bunker Hill
Cowpens
Long Island
Answer:
The Answer is D
Explanation:
:)
Which group advocated the abolition of central government in order to achieve greater social justice?
This question is incomplete. Here's the complete question.
The answer options are not provided. However, the question provides enough information to answer.
Answer: anarchists
Explanation:
Anarchism is a theory developed during the late 19th century and the early 20th century. Anarchists claim that the government is not necessary and it´s even dangerous.
Their ideas against laws, property, and any kind of authority, are meant to lead to real justice, based on the human inherent inclination to exercise mutual support.
Answer:
Anarchists
Explanation:
Before the French and Indian War, Spain had controlled Florida for
under fifty years.
over five hundred years.
over two hundred years.
under twenty years.
Answer:
Explanation:
300 years
The parties signed the Adams-Onis Treaty in 1819, and the transfer officially took place on July 17, 1821, over 300 years after Spain had first claimed the Florida peninsula.
...
Answer:
THE CORRECT ANSWER IS
*over two hundred years
Explanation:
the other person got it wrong. 300 aint an answer option. i took the test and got a 100. let me know if you have any more questions
plss help
Which action did prohibition supporters not take to further their cause?
A.
They burned down local saloons.
B.
They disrupted businesses that sold alcohol.
C.
They produced and distributed pamphlets.
D.
They lobbied elected officials.
Answer: I answered A. I’m not sure if it is right. Please tell me if you got it right.
Explanation: I don’t remember anything about the burning of local saloons.
Answer:
its A
Explanation:
i got it right on my practice
How does Henry Garnet use religion as part of his argument against slavery?
Answer:
Idk idk
Explanation:
Answer:
Read the following quote from Frederick Douglass:
“Verily, the work does not end with the abolition of slavery, but only begins.”
What does Douglass mean by this statement? What work might need to be done in 1865?
Explanation:
Jayden is writing a DIY (do it yourself) article about how to make your own Christmas ornaments using items from around your house. Which organizational technique would likely work BEST for Jayden’s article?
problem and solution
pros and cons
spatial pattern
sequential order
Answer:
sequentail order
Explanation:
cause you r listing things and going step by step
The simple interest rate on a loan of 200$ at 10% interest per year is
A- 10$
B-15$
C- 20$
D- 25$
Respond to the following prompt in paragraph form: Compare the Progressive Era (1900-1920) to the current state of America. How do these two time periods compare (similarities)? How are these time periods different? You should include an introduction, similarities paragraph, differences paragraph, and a conclusion.
Answer:
During the Progressive era, a series of reforms were made to fix some problems that came with industrialization. One of those problems was women and child labor.
Child and female labor reforms were created during the progressive era to provide safer conditions for women and children to work. They were set a limit of hours day and week of labor.
Also, education became more important during the Progressive era, even though children were still hired for work they also went to school more.
A series of laws were passed in Oregon, Illinois, Virginia, Michigan, Louisiana, and other states that prohibited women from working more than 10 hours a day.
Explanation:
Elizabeth was the daughter of Henry VIII and
Catherine Parr
Answer:
true
Explanation:
rights are basic rights to which all humans are entitled.
Answer:
Thats the answer to the question, What is human rights?
Explanation:
Human rights are inherited to all human/ people!
Answer:
B. Natural
Explanation:
Why did our Founding fathers create a system of checks and balances between the three branches of government.
Answer:
The Founding Fathers, the framers of the U.S. Constitution, wanted to form a government that did not allow one person to have too much control.
Explanation:
A branch may use its powers to check the powers of the other two in order to maintain a balance of power among the three branches of government
what is the reason for the sugar act?
Answer:
Down
Explanation:
to raise revenue to help provide money to pay the military costs of protecting the american colonies at he time when the british empire was saddled with a huge debt
if you have instructions or knowledge to complete a task you have
Answer:
direction
Explanation:
Given that Direction is a term that is used to describe guidance, or instruction to follow when a certain assignment or duty is to be completed or done by an individual or group of people. Hence, in a situation where individuals have instructions or knowledge to complete a task such individuals have DIRECTION.
Hence, the correct answer, in this case, is DIRECTION