Answer:
The vitamin D receptor (VDR) is present in mammary gland, and VDR ablation is associated with accelerated glandular development during puberty. VDR is a nuclear receptor whose ligand, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] is generated after metabolic activation of vitamin D by specific vitamin D hydroxylases. In these studies, we demonstrate that both the VDR and the vitamin D 1-alpha hydroxylase (CYP27B1), which produces 1,25-(OH)(2)D are present in mammary gland and dynamically regulated during pregnancy, lactation, and involution. Furthermore, we show that mice lacking VDR exhibit accelerated lobuloalveolar development and premature casein expression during pregnancy and delayed postlactational involution compared with mice with functional VDR. The delay in mammary gland regression after weaning of VDR knockout mice is associated with impaired apoptosis as demonstrated by reductions in terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining, caspase-3 activation and Bax induction. Under the conditions used in this study, VDR ablation was not associated with hypocalcemia, suggesting that altered mammary gland development in the absence of the VDR is not related to disturbances in calcium homeostasis. Furthermore, in the setting of normocalcemia, VDR ablation does not affect milk protein or calcium content. These studies suggest that the VDR contributes to mammary cell turnover during the reproductive cycle, and its effects may be mediated via both endocrine and autocrine signaling pathways. Unlike many mammary regulatory factors that exert transient, stage-specific effects, VDR signaling impacts on mammary gland biology during all phases of the reproductive cycle.
Explanation:
i-summarize niyo nalang po
Use trigonometric identities to verify each expression is equal. csc2(x) - 2csc(x)cot(x) + cot2(x) = tan2(x/2)
By definition of csc and cot,
csc²(x) - 2 csc(x) cot(x) + cot²(x) = …
… = 1/sin²(x) - 2 cos(x) / sin²(x) + cos²(x) / sin²(x)
Combining fractions,
… = (1 - 2 cos(x) + cos²(x)) / sin²(x)
Factorize the numerator and use the Pythagorean identity,
cos²(x) + sin²(x) = 1,
to rewrite the denominator.
… = (1 - cos(x))² / (1 - cos²(x))
Cancel a factor of 1 - cos(x).
… = (1 - cos(x)) / (1 + cos(x))
Using the half-angle identities,
sin²(x) = (1 - cos(2x))/2
cos²(x) = (1 + cos(2x))/2
it follows that
1 - cos(x) = 2 sin²(x/2)
1 + cos(x) = 2 cos²(x/2)
and so
… = (2 sin²(x/2)) / (2 cos²(x/2))
… = sin²(x/2) / cos²(x/2)
Finally, by definition of tangent,
… = tan²(x/2)
Explain the relationship between energy and economic development. Brainly.
A number is equal to 3 times a smaller number. Also, the sum of the smaller number and 4 is the larger number. The situation is graphed on the coordinate plane below, where x represents the smaller number and y represents the larger number. On a coordinate plane, a line goes through (0, 4) and (2, 6) and another line goes through (1, 3) and (2, 6). Which two equations represent the situation?.
Answer:
C
Explanation:
I did the quiz
The two equations that represent the situation are y = 3x and y = x + 4. The correct option is c.
What is coordination?Coordinates are two numbers (Cartesian coordinates) or a letter and a number that point to a specific point on a grid known as a coordinate plane. A coordinate plane has four quadrants and two axes: x (horizontal) and y (vertical).
The horizontal and vertical distances from the two reference axes are used to describe the position of a point on a coordinate plane.
X and its values on the x coordinate represented the smaller integer. y and its values on the y coordinate represented the greater integer. The larger number is three times the smaller number. This implies that
y = 3x
Also, the larger number is the sum of the smaller and larger numbers. This implies that y = x + 4
Therefore, the correct option is c, y = 3x and y = x + 4.
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The question is incomplete. Your most probably complete question is given below:
y = one-third x and y = x minus 4 y = one-third x and y = x + 4 y = 3 x and y = x + 4 y = 3 x and y = x minus 4.
Matthew has a loyalty card good for a discount at his local hardware store. The item he wants to buy is priced at $13, before discount and tax. After the discount, and before tax, the price is $12. 48. Find the percent discount.
Which of the following is a limited quantity item?.
Answer:
Plzzz add options? then I will answer fully?
Explanation:
Nail polish ad Lithium batteries exist in Limited quantity items.
What is a limited quantity item?A limited quantity exists a phrase utilized in safe transportation and represents the highest quantity of packages to authorize the transport of dangerous goods.
Limited quantity items exist usually filled in boxes during transport.
Nail polish ad Lithium batteries have a chemical that is disastrous and hazardous if negligently packaged.
Thus, in close, Nail polish ad Lithium batteries exist as examples of Limited quantity items.
Complete question:
Which of the following is a limited quantity item
Nail polish
Matches
Lithium batteries
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Each of the following sentences from the youngest doll contains an example of magical realism except.
All of the options given contain an example of magic realism except: B. the aunt designs and crafts dolls as gifts for her nieces.
Magic realism is a genre of writing that incorporates myth into realities. In option B, we do not see an example of magic realism because there is no infusion of magic in the events narrated.
The aunt simply designed and crafted dolls for her nieces. This is purely realistic. There is no element of magic here.
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Properties of protein is least likely to be affected by change in ph.
Answer:
Given
Rate of interest = 10% per annum
Principal for the first year = Rs 6000
Interest for the first year = Rs (6000 × 10 × 1) / 100
= Rs 600
Amount at the end of first year = Rs 6000 + Rs 600
= Rs 6600
Principal for the second year = Rs 6600
Interest for the second year = Rs (6600 × 10 × 1) / 100
= Rs 660
Amount for the second year = Rs 6600 + Rs 660
= Rs 7260
Therefore, compound interest for 2 years = final amount – (original) Principal
= Rs 7260 – Rs 6000
We get,
= Rs 1260
What is one technique to help a person get proper sleep.
A human fingernail has a hardness of approximately 2. 5. Which two minerals are softer than a human fingernail?.
Answer:
gypsum and talc
Explanation:
gypsum has 2 hardness and talc has 1
Which of the following is a potential drawback to using ninhydrin?.
Answer:
I need only 5 brainlisted please give me
Which phrase from the passage best helps the reader to identify the passage as a satire.
Answer:
can u please put a pic of the Passage so I can answer?
A. Define dual enrollment.
B. What is another name for dual enrollment?
The total area of two square windows is 1,025 in. 2. Each side of the larger window is 5 in. Longer than the sides of the smaller window. How long are the sides of the smaller window? a = s2 13. 5 in. 20 in. 25 in. 31. 6 in.
a student is standing 20 feet away from the base of a tree
Put the plot events from animal farm in the correct order.
Answer:
how can u put more detail please
What is the first step in solving the equation 3. 5 n + 6. 4 = 42. 5? add 6. 4 to each side of the equation. Subtract 6. 4 from each side of the equation. Multiply each side of the equation by 3. 5. Divide each side of the equation by 6. 4.
Answer:
3.5n+6.4=42.5
-6.4=-6.4
3.5n=36.1
————— (divide)
3.5=3.5
n=36.1/3.5 or 10.314
Explanation:
I'm confused by the question... is the question what is the first step of solving this equation?? and if it is, your answer is correct. which is subtract 6.4 for both sides.
There is one christmas ballet that charms them all. But do you know who composed "the nutcracker"?.
There are different great composers. The composer of "the nutcracker" was Pyotr Tchaikovsky.
The Nutcracker, is known to be a Russian Shchelkunchik, a ballet often performed during Christmas. It was composed by Pyotr Tchaikovsky. This was known to be the last of his three ballets and its first performance was done on December 1892.
The Nutcracker is a ballet that centers around children and the beauty of childhood. It was also known to be the first experience of a professional dance performance.
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It should be noted that the composer of "the nutcracker is Pyotr Tchaikovsky.
According to this question, we are required the details about the nutcracker and the composer of it.
As a result of this, we can see that the Nutcracker is been composed by Pyotr Tchaikovsky and was one of his three ballets in 1892.Pyotr Tchaikovsky is been regarded as Russian Shchelkunchik, and this is been performed around Christmas time.
Therefore, the composer of "the nutcracker is Pyotr Tchaikovsky.
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Pauline chasse has just signed a lease agreement with landlord, wayne godbrey to rent a house he owns in delano. The lease states definite beginning (january 1, 2016) and ending (october 30, 2016) dates, and sets forth the rent amount and due dates and all additional property and personal information required in such a lease. Wayne hands a copy to pauline, but she notices that he has not signed it. When she comments about this to him, he tells her that signatures are not necessary since the lease is for less than a year. Which of the following is true of this situation?.
The correct option that is true as regards Wayne's situation about the lease is;
B; Leases of less than one year are not required to be in writing. However, if a lease IS in writing, then it must be signed by the lessor (in this case, Wayne).
The missing options are;
Under the Statute of Frauds in California,
A) leases of less than one year are not even required to be in writing, and therefore, signatures are not required.
B) Leases of less than one year are not required to be in writing. However, if a lease IS in writing, then it must be signed by the lessor (in this case, Wayne).
C) Leases of less than one year are not required to be in writing; but if there is a written lease, then it must be signed by both the lessee and lessor.
D) Because the property being leased is located in Northern California, a lease agreement is required to be both written and signed by the lessor if the lease period is for 6 months or more
Now, California has some principles that guide the regulation of the real estate industry and according to the California Principles of Real State, it has to be said that leases of less than one year are not required to be in writing. Now, even though the law stated that the consent of both parties are not enough to bind themselves in the lease agreement, it is recommended that just for the sake of keeping things legally binding as regards the agreement between both parties, then both parties may state it in written and the lessor must sign it.Read more about real estate statutes at; https://brainly.com/question/19655487
Change the following to improper fraction or mixed number 35/8.
Answer:
4 3/8
Explanation: Step 1 - Find Whole Number.
35 / 8 = 4.3750 = 4
35 - (8 x 4) = 3 Step 2 - Find New Numerator
Which of the following processes requires molecular o2 as a reactant?.
The process that requires molecular oxygen as a reactant is: the Electron Transport System.
The Electron Transport System consists of a number of electron transporters in the inner mitochondrial membrane that are charged with moving electrons from the NADH and FADH₂ to molecular oxygen.
The final result of the electron transport system is the reduction of oxygen to water.
So, of all of the options provided, that which requires molecular oxygen as a reactant is the electron transport system.
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These are the options:
(a) Glycolysis
(b) Lactic acid production
(c) Electron transport system
(d) Fermentation
(e) None of the above.
If the speaker says, "we’re gonna go to paris in a few days, um, then we’re off to venice," you would caption it this way:.
The way the given speech could be captioned is that; We’re going to go to Paris in a few days, then we’re off to Venice.
From the given speech of the speaker, we can see that it is a direct speech as the exact words he used and the other words are all quoted in inverted commas.
Whereas, In indirect speech, the exact words used by the speaker are not quoted.
The best way to caption the speech is that the inverted commas will removed as well as well as the conjunction used and we will make it an indirect speech as follows;
We’re going to go to Paris in a few days, then we’re off to Venice.
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Amo a mis hermanas. Los amo. Amo las. Las amo. La amo.
La oración Amo a mis hermanas es equivalente a Las amo.
En esta pregunta debemos determinar la forma abreviada equivalente a la oración dada (Amo a mis hermanas), puesto que el complemento directo está asociado a un sujeto femenino en tercera persona del plural, se debe emplear un artículo definido femenino en plural (Las)
Por tanto, la oración Amo a mis hermanas es equivalente a Las amo.
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Answer:
Amo a mis hermanas.
Los amo.
Amo las.
Las amo.
La amo.
ANSWER IS LAS AMO
Explanation:
The nims management characteristic of information and intelligence management may include surveillance of disease outbreaks.
Answer: It's True
Hopefully it's right
A force of 5000n is applied outwardly to each end of a 5. 0-m long rod with a radius of 34. 0 cm and a young's modulus of 125 × 108 n/m2. The elongation of the rod is: phy101.
The elongation of the rod is [tex]5.51 \times 10^{-4}m[/tex]`
Young Modulus of a substanceThe young modulus of a substance is the ratio of stress to the strain of material.
[tex]Modulus = \frac{Stress}{Strain}\\ Modulus =\frac{Fl}{Ae}[/tex]
where:
F is the applied force = 5000Nl is the length of the rod = 5.0mA is the cross-sectional area = [tex]\pi r^2 = 0.34^2 * 3.14 =0.362984m^2[/tex]
Required
Extension of the rod "e"
Substitute the given parameters into the formula to have;
[tex]e=\frac{Fl}{A \gamma} \\e=\frac{5000 \times 5}{0.362984 \times 125,00,000}\\e=\frac{25000}{45,373,000}\\e= 5.51 \times 10^{-4}m[/tex]
Hence the elongation of the rod is [tex]5.51 \times 10^{-4}m[/tex]`
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which statement best describes how the author uses language in the passage? the author uses metaphor and simile to compare autumn to various elements found in nature. the author uses apostrophe to help the reader form an objective, detached view of autumn. the author uses a simple, logical style to explain to the reader what autumn is really like. the author uses imagery and personification to make autumn seem friendly and generous to the reader.
There are different kinds of Language. The statement that best describes how the author uses language in the passage is that the author uses imagery and personification to make Autumn seem friendly and generous to the reader.
Personification is simply known to be used when one wants to use human qualities on an object e.g. Close bosom-friend of the maturing sun
Imagery is simply known to be used also to describe something using things that people don't know especially those that have not seen or heard of it. e.g. With fruit the vines that round the thatch-eves run.
See full question below
Read the passage from "To Autumn."
Season of mists and mellow fruitfulness,
Close bosom-friend of the maturing sun;
Conspiring with him how to load and bless
With fruit the vines that round the thatch-eves run;
To bend with apples the moss'd cottage-trees,
And fill all fruit with ripeness to the core
Which statement best describes how the author uses language in the passage?
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Answer:
A.
Explanation:
The author uses metaphor and simile to compare autumn to various elements found in nature.
The speaker of which statement would be best served by joining an interest group?.
Which of the following best describes the long-term impact of using a renewable energy source?.
biomass releases great house gasses when burned and this is a long term impact of a renewable energy source.
List the angles of ∆ abc from smallest to largest. Ab = 20, bc = 12, ca = 10.
The angle of the triangle ABC from smallest to largest are approximately 22°, 27° and 131°.
The sides of the triangle are as follows;
AB = 20
BC = 12
AC = 10
Let's find ∠A using cosine rule,
a² = b² + c² - 2bc cos A
cos A = b² + c² - a² / 2bc
Therefore,
cos A = 10² + 20² - 12² / 2 × 10 × 20
cos A = 100 + 400 - 144 / 400
cos A = 356 / 400
cos A = 0.89
A = cos⁻¹ 0.89
A = 27.1267531173
∠A ≈ 27°
Using sine rule let's find ∠B
12 / sin 27 = 10 / sin B
cross multiply
12 sin B = 10 sin 27
sin B = 10 sin 27 / 12
sin B = 10 × 0.45399049974 / 12
sin B = 4.5399049974 / 12
B = sin⁻¹ 0.37832541645
B = 22.2299936087
∠B = 22°
Using sum of triangle theorem let's find ∠C
∠C = 180 - 27 - 22
∠C = 131°
The angles from smallest to largest are approximately 22°, 27° and 131°.
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Which of the following is a criticism of piaget's cognitive development theory?.
Answer:
ANSWER IS
Explanation:
The cognitive stages are not as fixed or rigid as Piaget proposed. ... Piaget may have underestimated the role that parents and other people play in a child's intellectual development. Some psychologist believe that we can 'hothouse' children so they develop at a quicker rate. Piaget ignored different kinds of thinking.
Accelerated mammary gland development in intellectually disabled females.
A mammary gland simply means the gland that's located in the female's breasts and it's responsible for lactation.
Your information is incomplete. Therefore, an overview of the topic will be given. It should be noted that males and females have glandular tissue within their breasts.
In females, the glandular tissues develop after puberty. The mammary glands are responsible to produce milk. It is typically regulated by hormones.
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